This report presents the first feasibility evaluation of 3-dimensional (3D) holographic guidance and navigation for performing percutaneous thermal ablation of solid tumors. The HoloLens augmented reality headset (Microsoft, Redmond, WA) was used to intraprocedurally a) project patient-specific, true 3D holograms of anatomical structures and b) track interventional instruments in spatial registration with (while seeing through to) the real (physical) operative site (1).